Different Kinds of Advanced Prostate Cancer

Prostate cancer that gets worse or spreads despite treatment to lower testosterone is called castration-resistant prostate cancer (CRPC).

  • If your CRPC has not spread to other parts of your body, it is called non-metastatic CRPC (nmCRPC)
  • If your CRPC has spread to other parts of your body, it is called metastatic CRPC (mCRPC)

Cancer That Has Not Spread

If your doctor determined that you have non-metastatic CRPC, it means 3 things:

  • Your prostate cancer is no longer responding to medical or surgical treatments that lower testosterone
  • Even though your testosterone is at low levels (50 ng/dL or less), your PSA levels continue to rise
  • Imaging scans show that your prostate cancer has not spread to other parts of your body

Cancer That Has Spread

If your doctor determined that you have metastatic CRPC, it means 3 things:

  • Your prostate cancer is no longer responding to medical or surgical treatments that lower testosterone
  • Even though your testosterone is at low levels (50 ng/dL or less), your PSA levels continue to rise
  • Imaging scans show that your prostate cancer has spread to other parts of your body

Where can prostate cancer spread? In many cases, the cancer cells travel to the bones first. Prostate cancer can also spread to the lymph nodes, bladder, lungs, and liver.